What is Re² Double Collagen Booster?
Two powerhouses. One exceptional result. Re² Double Collagen Booster is a doctor-administered injectable treatment that combines two of the most clinically compelling ingredients in skin regeneration — salmon-derived polynucleotides (PN) and human acellular dermal matrix (hADM) — in a single, synergistic programme. Where PN repairs and regenerates at a cellular level, hADM directly replenishes the skin's structural foundation. Together, they address skin quality from two distinct but complementary angles, delivering a depth of collagen support and skin renewal that neither could achieve alone.
Treatment Snapshot
Sessions
3–4
spaced 1-2 months apart
Downtime
0 hrs
From
$1,288
How It Works
Re² works by combining two regenerative mechanisms that target different but complementary layers of skin quality: Polynucleotides (PN) — salmon-derived, biocompatible polynucleotides work at a cellular level to stimulate skin regeneration, activate collagen and elastin production, reduce inflammation, and accelerate the skin's natural repair processes. PN essentially signals the skin to heal and renew itself from within. Human Acellular Dermal Matrix (hADM) — derived from donated human skin tissue and processed to remove all cells, DNA, and antigenic components, hADM directly replenishes the extracellular matrix (ECM), the skin's internal scaffolding of collagen, elastin, and structural proteins. Rather than stimulating collagen indirectly, it delivers the actual building blocks the skin needs to rebuild its foundation. Together, PN and hADM create a repair and rebuild cycle — PN activates the skin's regenerative response while hADM provides the structural raw material for that regeneration to work with. The result is a more comprehensive, longer-lasting improvement in skin quality than either ingredient could deliver independently.
What it treats.
Overall skin quality & texture
dualaction regeneration addresses both cellular repair and structural support for skin that looks and behaves genuinely healthier
What to expect.
Immediately after
skin feels more hydrated and refreshed. Mild redness, small bumps, or tenderness at injection points may occur and typically resolve within 24–48 hours.
2–4 weeks
early improvements in skin texture, hydration, and overall quality become visible as both ingredients begin to work.
3–6 months
continued collagen synthesis and ECM replenishment support longer-lasting firmness, smoother texture, and a more even, radiant complexion.
Immediately after
skin feels more hydrated and refreshed. Mild redness, small bumps, or tenderness at injection points may occur and typically resolve within 24–48 hours.
2–4 weeks
early improvements in skin texture, hydration, and overall quality become visible as both ingredients begin to work.
3–6 months
continued collagen synthesis and ECM replenishment support longer-lasting firmness, smoother texture, and a more even, radiant complexion.
How long do results last?
Results typically last 6–12 months, depending on skin condition, lifestyle, and individual response. Periodic maintenance sessions help sustain and build on the improvements over time.
How often should I return?
3–4 sessions spaced one month apart for the initial programme, followed by maintenance every 6–12 months as recommended by your doctor.
Combination Care
Re² pairs well with surface laser treatments such as the Luminance Glow Laser or Tetra 4-in-1 Laser for deeper regeneration alongside surface brightening.
This is for you if you…
Want a more comprehensive skin regeneration approach than a single booster can offer
Are looking to address both surface skin quality and deeper structural support in one programme
Have tried individual skin boosters and want to take their results to the next level
Experience acne scarring, skin laxity, sensitivity, or overall skin quality concerns
Prefer a natural-looking, gradual improvement backed by two of the most clinically researched regenerative ingredients available
Good to know.
Not sure where to begin?
Try our AI Skin AnalysisYes. Both polynucleotides (PN) and human acellular dermal matrix (hADM) are biocompatible, well-researched ingredients with strong safety profiles. hADM is fully processed to remove all cells and antigenic components, making it well-tolerated by most skin types. All treatments at Reborn are administered by licensed doctors, with suitability assessed individually before every session.
Most find the procedure tolerable. You may feel brief stinging or mild pressure at each injection point. A medical-grade numbing cream is applied beforehand for comfort.
Minimal. Mild redness, small bumps, or tenderness at injection points typically fade within 24–48 hours. Most resume normal activities shortly after treatment.
Early improvements in skin texture and hydration are often noticeable after the first session. Optimal results typically develop after completing the recommended course as both ingredients integrate and work progressively within the skin.
Most skin boosters address one aspect of skin quality — either cellular repair or structural support. Re² combines both in a single programme, targeting skin regeneration at two complementary levels for a more comprehensive and longer-lasting result.
Typically 3–4 sessions spaced one month apart, followed by maintenance every 6–12 months. Your doctor will personalise a plan based on your skin condition and goals.
Disclaimer
Individual results may vary based on skin condition, lifestyle, and treatment plan. All treatments are doctor-administered. Suitability is assessed at consultation.